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More than 230 patients enrolled in the second phase of the study, many of them in Boston, and researchers at Karyopharm Therapeutics Inc say they’re making progress. We want you to take advantage of everything Cancer Therapy Advisor has to offer. Bristol Myers Squibb (NYSE: BMY) and Bluebird Bio (NASDAQ: BLUE) are advancing an experimental CAR-T therapy for multiple myeloma. are not responsible for the accuracy of news releases posted to EurekAlert!  @worldwidecancer, Copyright © 2020 by the American Association for the Advancement of Science (AAAS), Dr. Tuna Mutis, VU University Medical Center, The Institute of Medical Science, The University of Tokyo, National Institute of Information and Communications Technology (NICT), Invested £200m into cancer research worldwide, Devoted £100m to cancer research in the UK, Funded 2000 projects in over 30 countries. Cancer cells can become resistant to treatment by recruiting surrounding healthy cells to support them. Patients with advanced multiple myeloma have a new treatment option with the FDA’s approval of a GlaxoSmithKline drug that … © 2007-2020, Xconomy, Inc. "We haven’t seen any safety issues that we are worried about. Researchers at the VU University Medical Center in the Netherlands have tested a new drug in patient samples and mice with multiple myeloma and discovered that it was effective even in advanced disease - a point when many patients currently run out of options. Closer scrutiny of individual patient data suggests the results may be even more promising than they first appear, he explained. The new drug, called FL118, has previously shown promise when tested on colon and head and neck cancer cells in the lab. “The responses deepen over time,” Dr Bakker said. According to the researchers, FL118 could be used in combination with currently used drugs to overcome treatment resistance. The single-arm HORIZON trial enrolled 157 patients with a median of 5 prior lines of therapy. Multiple myeloma is a plasma cell cancer that occurs in bone marrow. Walk-Up Docs Donated to Low-Income Areas for Coronavirus Testing, ‘Hey, Can You Put a Mask on?' Close more info about New Class of Drug Appears to Extend Survival in Patients With Triple-Refractory Multiple Myeloma, Inpatient Mortality With Renal Impairment in Patients With Multiple Myeloma. Sarah de Crescenzo is an Xconomy editor based in San Diego. Issued by Worldwide Cancer Research. "We’re encouraged by what we are seeing," CEO Dr. Michael Kauffman said. Multiple myeloma accounts for 1% of all cancers and approximately 10% of all hematologic malignancies. EurekAlert! You’ve read {{metering-count}} of {{metering-total}} articles this month. The goal is to keep patients with the most severe cases off a ventilator. Follow @sarahdc, Insights, wisdom, and inspiration on what it takes, Industry experts explain what it takes to launch a new biotech company. Our collaborators, who also provided this compound, are now planning this trial. “The HORIZON population represents 1 of the largest sets of patients with this Triple-class–refractory disease, and with melflufen in this population we show a 26.1% overall response rate.”. When tested in a mouse model of multiple myeloma, FL118 was able to reduce tumour volume to almost one sixth of its original size and delayed tumour growth for up to 5 weeks. Patients that received the GSK (NYSE: GSK) drug in the trial, dubbed DREAMM-2, had previously undergone a median of seven prior lines of treatment. March 27, 2020 New drug could reverse treatment resistance in advanced multiple myeloma by Worldwide Cancer Research Micrograph of a plasmacytoma, the histologic correlate of multiple myeloma. Durie covers the potential FDA approvals of such agents as belantamab mafodotin, bb2121, a new isatuximab combination, a new Kyprolis® combination, melflufen, and venetoclax. Approval for belantamab mafodotin as a treatment for multiple myeloma is seen as important for GSK's growing oncology portfolio. The researchers found that not only is FL118 effective at killing multiple myeloma cells when they are surrounded by these support cells, but it was also able to reverse treatment resistance. The agency OK’d the London-based pharma giant’s cancer drug, belantamab mafodotin (Blenrep), based on the results of a study in which patients with the blood cancer received the drug intravenously every three weeks until their disease progressed or the side effects became too much to handle. For 73 percent of those patients, the response lasted six months or more. The duration of response only counts the time after the cancer shows a partial response or better, but many patients had several months of stable disease before achieving partial response. This material may not be published, broadcast, rewritten or redistributed in any form without prior authorization. 1 Each year over 32 000 new cases are diagnosed in the United States, and almost 13 000 patients die of the disease. We need to make sure that more bold new ideas like this are funded if we want to keep one step ahead of cancer.". The FDA OK’d belantamab mafodotin for patients who have received at least four prior treatments, including an antibody drug targeting the protein CD38, a proteasome inhibitor, and an immunomodulator. Bold research will cure cancer - but we can't do it alone. A new type of myeloma treatment called CC-92480 (a CELMoD) showed benefit in a Phase I international clinical trial at the recent ASCO 2020 meeting.. 01-313-700-345 Treatment resistance is a huge problem in cancer patients and exciting discovery research like this tackles this issue head on. 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