September 3, 2020

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Its prevalence varies considerably across the world but it is found in about 8% of the UK population. The HLA-B27 test is primarily requested to help strengthen or confirm a suspected diagnosis of ankylosing spondylitis (AS), reactive arthritis, juvenile rheumatoid arthritis (JRA), or sometimes anterior uveitis . Reference ranges are dependent on many factors, including patient age, sex, sample population, and test method, and numeric test results can have different meanings in different laboratories. The test determines the presence or absence of HLA-B27 on the surface of a person's white blood cells (leucocytes). Several thousand different types are known. Often, the initial symptoms are subtle and it is commonly several years before characteristic degenerative changes to bones and joints are visible on X-ray. Ankylosing spondylitis: about 95% are HLA-B27 positive, and 5% are negative, Reactive arthritis: about 60-85% are HLA-B27 positive, Isolated acute anterior uveitis: about 40-70% are HLA-B27 positive. British Society of Rheumatology Because HLA-B27 is common, its presence does not prove the presence of the disorder. HLA A is one of three major types (HLA A, HLA B, HLA C) of human major histocompatability complex class I cell surface receptors. It is not typically performed in a doctor's office and is not offered by every laboratory. To find out whether you have human leucocyte antigen B27 (HLA-B27) on the surface of your cells; to help assess whether you might have an autoimmune disorder associated with the presence of HLA-B27, When you have symptoms of chronic inflammation, pain, and stiffness in certain areas of your body, such as your back, neck, and chest, or the interior portion of your eyes uveitis, especially if you are male and the symptoms began between late teens and your early 30s, A blood sample taken from a vein in your arm. However, it is helpful as one piece of evidence amongst others like signs, symptoms, and other lab tests to support or rule out the diagnosis of these disorders. Arthritis Research UK Similarities between the HLA-B27 protein and the proteins found on the surface of the microorganisms have also been found and this similarity may trigger the immune system to fight both the microorganism and the person's own tissues, launching the autoimmune disorder after the resolution of the infection. If you are concerned about your test results, you will need to arrange an appointment with your doctor so that all relevant information including age, ethnicity, health history, signs and symptoms, laboratory and other procedures (radiology, endoscopy, etc. For these reasons, you will not find reference ranges for the majority of tests described on this web site. AS is a chronic, progressive condition that occurs more frequently in men than women. Anterior uveitis is associated with recurring inflammation of the structures of one or both eyes. HLA-B27 is also more common in people with spondylitis associated with inflammatory bowel disease and psoriatic arthritis. Every nucleated cell in your body has proteins protruding from the cell surface called human leucocyte antigens (HLA). The most common in the U.K. are HLA-B27*05, HLA-B27*04 and HLA B27*02. The test result must be interpreted in the context of the clinical symptoms and signs. This test checks your blood for antibodies against a cell marker called a human leukocyte antigen (HLA). In most cases, your blood sample will be sent to a reference laboratory. Your GP practice will be able to provide specific details. HLA-B27 has not been established as a cause of these disorders but HLA-B27 positivity is more common in people with these disorders than in people without them. An HLA-B27 test may be requested when a person has acute or chronic pain and inflammation in the spine, neck, chest, eyes, and/or joints, and the doctor suspects an autoimmune disorder that is associated with the presence of HLA-B27. This group of tests may include an RF (rheumatoid factor) with an ESR (erythrocyte sedimentation rate) and a CRP (C-Reactive protein). An HLA-B27 may also be ordered when someone has recurrent uveitis. HLA genes are highly polymorphic, which means that they have many different alleles, allowing them to fine-tune the adaptive immune system. © 2001-2020 by American Association for Clinical Chemistry, BRCA-1 and BRCA-2 (Breast Cancer Gene 1 and 2) Tests, Factor V Leiden Mutation and PT 20210 Mutation, Faecal Occult Blood Test and Faecal Immunochemical Test, First Trimester (Combined) Screen for Down’s Syndrome and other fetal anomalies, Heparin-induced Thrombocytopenia Antibody, Plasma Free Metadrenalines (Metanephrines), Protein Electrophoresis and Immunofixation Electrophoresis, Red Blood Cell (RBC) Antibody Identification, Unvalidated or misleading laboratory tests, Urine Protein and Urine Protein to Creatinine Ratio, Adrenal Insuficiency and Addison's Disease, Staph Wound Infections and Methicillin Resistant, Screening Tests for Adults (age 50 and above). 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